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Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Drosophila

Huntington’s disease (HD) is a neurodegenerative disease characterized by movement and cognitive dysfunction. HD is caused by a CAG expansion in exon 1 of the HTT gene that leads to a polyglutamine (PQ) repeat in the huntingtin protein, which aggregates in the brain and periphery. Previously, we use...

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Detalles Bibliográficos
Autores principales:	Roth, Jonathan R., de Moraes, Ruan Carlos Macedo, Xu, Brittney P., Crawley, Savannah R., Khan, Malghalara A., Melkani, Girish C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562706/ https://www.ncbi.nlm.nih.gov/pubmed/37823007 http://dx.doi.org/10.3389/fnagi.2023.1223911

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