A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint

Misfolded glycoprotein recognition and endoplasmic reticulum (ER) retention are mediated by the ER glycoprotein folding quality control (ERQC) checkpoint enzyme, UDP-glucose glycoprotein glucosyltransferase (UGGT). UGGT modulation is a promising strategy for broad-spectrum antivirals, rescue-of-secr...

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Detalles Bibliográficos
Autores principales: Guay, Kevin P., Ibba, Roberta, Kiappes, J.L., Vasiljević, Snežana, Bonì, Francesco, De Benedictis, Maria, Zeni, Ilaria, Le Cornu, James D., Hensen, Mario, Chandran, Anu V., Kantsadi, Anastassia L., Caputo, Alessandro T., Blanco Capurro, Juan I., Bayo, Yusupha, Hill, Johan C., Hudson, Kieran, Lia, Andrea, Brun, Juliane, Withers, Stephen G., Martí, Marcelo, Biasini, Emiliano, Santino, Angelo, De Rosa, Matteo, Milani, Mario, Modenutti, Carlos P., Hebert, Daniel N., Zitzmann, Nicole, Roversi, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562782/
https://www.ncbi.nlm.nih.gov/pubmed/37822503
http://dx.doi.org/10.1016/j.isci.2023.107919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562782/
https://www.ncbi.nlm.nih.gov/pubmed/37822503
http://dx.doi.org/10.1016/j.isci.2023.107919

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