Cargando…
A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint
Misfolded glycoprotein recognition and endoplasmic reticulum (ER) retention are mediated by the ER glycoprotein folding quality control (ERQC) checkpoint enzyme, UDP-glucose glycoprotein glucosyltransferase (UGGT). UGGT modulation is a promising strategy for broad-spectrum antivirals, rescue-of-secr...
Autores principales: | Guay, Kevin P., Ibba, Roberta, Kiappes, J.L., Vasiljević, Snežana, Bonì, Francesco, De Benedictis, Maria, Zeni, Ilaria, Le Cornu, James D., Hensen, Mario, Chandran, Anu V., Kantsadi, Anastassia L., Caputo, Alessandro T., Blanco Capurro, Juan I., Bayo, Yusupha, Hill, Johan C., Hudson, Kieran, Lia, Andrea, Brun, Juliane, Withers, Stephen G., Martí, Marcelo, Biasini, Emiliano, Santino, Angelo, De Rosa, Matteo, Milani, Mario, Modenutti, Carlos P., Hebert, Daniel N., Zitzmann, Nicole, Roversi, Pietro |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562782/ https://www.ncbi.nlm.nih.gov/pubmed/37822503 http://dx.doi.org/10.1016/j.isci.2023.107919 |
Ejemplares similares
-
Crystal polymorphism in fragment-based lead discovery of ligands of the catalytic domain of UGGT, the glycoprotein folding quality control checkpoint
por: Caputo, Alessandro T., et al.
Publicado: (2022) -
Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells
por: Tax, Gábor, et al.
Publicado: (2023) -
Quantitative glycoproteomics reveals cellular substrate selectivity of the ER protein quality control sensors UGGT1 and UGGT2
por: Adams, Benjamin M, et al.
Publicado: (2020) -
Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose: Glycoprotein glucosyltransferase
por: Modenutti, Carlos P., et al.
Publicado: (2021) -
Selective involvement of UGGT variant: UGGT2 in protecting mouse embryonic fibroblasts from saturated lipid-induced ER stress
por: Hung, Hui-Hsing, et al.
Publicado: (2022)