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Endothelial barrier dysfunction in systemic inflammation is mediated by soluble VE-cadherin interfering VE-PTP signaling

Breakdown of endothelial barrier integrity determines organ dysfunction and outcome of patients with sepsis. Increased levels of soluble vascular endothelial (VE)-cadherin fragments (sVE-cadherin) have previously been linked with inflammation-induced loss of endothelial barrier function. We provide...

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Detalles Bibliográficos
Autores principales: Knop, Juna-Lisa, Burkard, Natalie, Danesh, Mahshid, Kintrup, Sebastian, Dandekar, Thomas, Srivastava, Mugdha, Springer, Rebecca, Hiermaier, Matthias, Wagner, Nana-Maria, Waschke, Jens, Flemming, Sven, Schlegel, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563049/
https://www.ncbi.nlm.nih.gov/pubmed/37822505
http://dx.doi.org/10.1016/j.isci.2023.108049