Knockout tales: the versatile roles of histone H3.3 in development and disease

Histone variant H3.3 plays novel roles in development as compared to canonical H3 proteins and is the most commonly mutated histone protein of any kind in human disease. Here we discuss how gene targeting studies of the two H3.3-coding genes H3f3a and H3f3b have provided important insights into H3.3...

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Autores principales: Klein, Rachel H., Knoepfler, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563256/
https://www.ncbi.nlm.nih.gov/pubmed/37814296
http://dx.doi.org/10.1186/s13072-023-00512-8
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author Klein, Rachel H.
Knoepfler, Paul S.
author_facet Klein, Rachel H.
Knoepfler, Paul S.
author_sort Klein, Rachel H.
collection PubMed
description Histone variant H3.3 plays novel roles in development as compared to canonical H3 proteins and is the most commonly mutated histone protein of any kind in human disease. Here we discuss how gene targeting studies of the two H3.3-coding genes H3f3a and H3f3b have provided important insights into H3.3 functions including in gametes as well as brain and lung development. Knockouts have also provided insights into the important roles of H3.3 in maintaining genomic stability and chromatin organization, processes that are also affected when H3.3 is mutated in human diseases such as pediatric tumors and neurodevelopmental syndromes. Overall, H3.3 is a unique histone linking development and disease via epigenomic machinery.
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spelling pubmed-105632562023-10-11 Knockout tales: the versatile roles of histone H3.3 in development and disease Klein, Rachel H. Knoepfler, Paul S. Epigenetics Chromatin Review Histone variant H3.3 plays novel roles in development as compared to canonical H3 proteins and is the most commonly mutated histone protein of any kind in human disease. Here we discuss how gene targeting studies of the two H3.3-coding genes H3f3a and H3f3b have provided important insights into H3.3 functions including in gametes as well as brain and lung development. Knockouts have also provided insights into the important roles of H3.3 in maintaining genomic stability and chromatin organization, processes that are also affected when H3.3 is mutated in human diseases such as pediatric tumors and neurodevelopmental syndromes. Overall, H3.3 is a unique histone linking development and disease via epigenomic machinery. BioMed Central 2023-10-10 /pmc/articles/PMC10563256/ /pubmed/37814296 http://dx.doi.org/10.1186/s13072-023-00512-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Klein, Rachel H.
Knoepfler, Paul S.
Knockout tales: the versatile roles of histone H3.3 in development and disease
title Knockout tales: the versatile roles of histone H3.3 in development and disease
title_full Knockout tales: the versatile roles of histone H3.3 in development and disease
title_fullStr Knockout tales: the versatile roles of histone H3.3 in development and disease
title_full_unstemmed Knockout tales: the versatile roles of histone H3.3 in development and disease
title_short Knockout tales: the versatile roles of histone H3.3 in development and disease
title_sort knockout tales: the versatile roles of histone h3.3 in development and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563256/
https://www.ncbi.nlm.nih.gov/pubmed/37814296
http://dx.doi.org/10.1186/s13072-023-00512-8
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