Cargando…

Astragalus polysaccharide restores insulin secretion impaired by lipopolysaccharides through the protein kinase B /mammalian target of rapamycin/glucose transporter 2 pathway

BACKGROUND: Lipopolysaccharide (LPS)-induced dysfunction of pancreatic β-cells leads to impaired insulin (INS) secretion. Astragalus polysaccharide (APS) is a bioactive heteropolysaccharide extracted from Astragalus membranaceus and is a popular Chinese herbal medicine. This study aimed to elucidate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ren, Xiaodan, Dai, Ying, Shan, Mengya, Zheng, Jing, Zhang, Zhongyi, Shen, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563267/ https://www.ncbi.nlm.nih.gov/pubmed/37817130 http://dx.doi.org/10.1186/s12906-023-04188-1

Ejemplares similares

Correction: Astragalus polysaccharide restores insulin secretion impaired by lipopolysaccharides through the protein kinase B/mammalian target of rapamycin/glucose transporter 2 pathway
por: Ren, Xiaodan, et al.
Publicado: (2023)

Amelioration of insulin resistance in rat cells by Astragalus polysaccharides and associated mechanisms
por: LIU, HONGZHI, et al.
Publicado: (2014)

Regulation of Human Trophoblast GLUT3 Glucose Transporter by Mammalian Target of Rapamycin Signaling
por: Xu, Jie, et al.
Publicado: (2015)

Astragalus polysaccharides alleviates lipopolysaccharides-induced inflammatory lung injury by altering intestinal microbiota in mice
por: Ming, Ke, et al.
Publicado: (2022)

Astragalus polysaccharide restores autophagic flux and improves cardiomyocyte function in doxorubicin-induced cardiotoxicity
por: Cao, Yuan, et al.
Publicado: (2016)

The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling
por: Yoon, Mee-Sup
Publicado: (2017)

Molecular Weight and Monosaccharide Composition of Astragalus Polysaccharides
por: Xu, Du-Juan, et al.
Publicado: (2008)

A Review of the Pharmacological Action of Astragalus Polysaccharide
por: Zheng, Yijun, et al.
Publicado: (2020)

Inhibitory Effect of Astragalus Polysaccharides on Lipopolysaccharide-Induced TNF-α and IL-1β Production in THP-1 Cells
por: He, Xiaojuan, et al.
Publicado: (2012)

Transforming somatic mutations of mammalian target of rapamycin kinase in human cancer
por: Yamaguchi, Hiroyuki, et al.
Publicado: (2015)

Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation
por: Li, Zhi-Peng, et al.
Publicado: (2018)

Effects of Apigenin and Astragalus Polysaccharide on the Cryopreservation of Bull Semen
por: Wang, Hongtao, et al.
Publicado: (2021)

Astragalus Polysaccharide Improves Insulin Sensitivity via AMPK Activation in 3T3-L1 Adipocytes
por: Zhang, Ruixin, et al.
Publicado: (2018)

α-Synuclein Regulates Peripheral Insulin Secretion and Glucose Transport
por: Wijesekara, Nadeeja, et al.
Publicado: (2021)

Extension of Drosophila Lifespan by Astragalus polysaccharide through a Mechanism Dependent on Antioxidant and Insulin/IGF-1 Signaling
por: Yang, Fujia, et al.
Publicado: (2021)

Optimization and evaluation of astragalus polysaccharide injectable thermoresponsive in-situ gels
por: Yu, Zugong, et al.
Publicado: (2017)

Wound healing effect of an Astragalus membranaceus polysaccharide and its mechanism
por: Zhao, Bingjiang, et al.
Publicado: (2017)

Effects of Astragalus Polysaccharides Nanoparticles on Cerebral Thrombosis in SD Rats
por: Sun, Qian, et al.
Publicado: (2020)

Synergist for antitumor therapy: Astragalus polysaccharides acting on immune microenvironment
por: Xu, Qian, et al.
Publicado: (2023)

Hypothalamic AMP-activated Kinase Regulates Glucose-stimulated Insulin Secretion
por: Koh, Eun Hee, et al.
Publicado: (2016)

Seabuckthorn polysaccharide combined with astragalus polysaccharide ameliorate alcoholic fatty liver by regulating intestinal flora
por: Liu, Jiayue, et al.
Publicado: (2022)

Can phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibition ERase them all?
por: Meyer, Dominique S, et al.
Publicado: (2010)

The mammalian target of rapamycin (mTOR) kinase mediates haloperidol-induced cataleptic behavior
por: Ramírez-Jarquín, Uri Nimrod, et al.
Publicado: (2020)

Cytoprotective effects of the medicinal herb Astragalus membranaceus on lipopolysaccharide-exposed cells
por: Wu, Xian, et al.
Publicado: (2018)

Astragalus polysaccharides inhibit oxidation in high glucose-challenged or SOD2-silenced H9C2 cells
por: Chen, Wei, et al.
Publicado: (2018)

Mitochondrial Protection and Anti-aging Activity of Astragalus Polysaccharides and Their Potential Mechanism
por: Li, Xing-Tai, et al.
Publicado: (2012)

Genotoxicity Study of Polysaccharide Fraction from Astragalus membranaceus's Aerial Parts
por: Park, Yeong-Chul, et al.
Publicado: (2014)

Modulatory Effects of Astragalus Polysaccharides on T-Cell Polarization in Mice with Polymicrobial Sepsis
por: Hou, Yu-Chen, et al.
Publicado: (2015)

Effects of Astragalus Polysaccharides on Dysfunction of Mitochondrial Dynamics Induced by Oxidative Stress
por: Huang, Yan-Feng, et al.
Publicado: (2016)

Effects of Astragalus polysaccharides on memory impairment in a diabetic rat model
por: Dun, Changping, et al.
Publicado: (2016)

Astragalus Polysaccharide Suppresses 6-Hydroxydopamine-Induced Neurotoxicity in Caenorhabditis elegans
por: Li, Haifeng, et al.
Publicado: (2016)

chTLR4 pathway activation by Astragalus polysaccharide in bursa of Fabricius
por: Ruili, Zhang, et al.
Publicado: (2017)

Astragalus Polysaccharide Promotes Adriamycin-Induced Apoptosis in Gastric Cancer Cells
por: Song, Jie, et al.
Publicado: (2020)

Protective Effects of Astragalus Polysaccharide on Sepsis-Induced Acute Kidney Injury
por: Sun, Jie, et al.
Publicado: (2021)

Structural Characterization and Immunobiological Activity of Polysaccharides from Astragalus Oyster Mushroom
por: Meng, Qiuxia, et al.
Publicado: (2023)

Astragalus polysaccharide improve the proliferation and insulin secretion of mouse pancreatic β cells induced by high glucose and palmitic acid partially through promoting miR-136-5p and miR-149-5p expression
por: Deng, Shifang, et al.
Publicado: (2021)

A Multi-Component Nano-Co-Delivery System Utilizing Astragalus Polysaccharides as Carriers for Improving Biopharmaceutical Properties of Astragalus Flavonoids
por: Yang, Bing, et al.
Publicado: (2023)

Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
por: Yang, Shi-Bing, et al.
Publicado: (2011)

Effect of plant polysaccharides (Poria cocos and Astragalus polysaccharides) on immune responses and intestinal microbiota of Dabry’s sturgeons
por: ZHANG, Jianming, et al.
Publicado: (2023)

Avian and Mammalian Facilitative Glucose Transporters
por: Byers, Mary Shannon, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_t828bfl3h85fd85rme1v7cqrqt