Local continual reassessment methods for dose finding and optimization in drug-combination trials

Due to the limited sample size and large dose exploration space, obtaining a desirable dose combination is a challenging task in the early development of combination treatments for cancer patients. Most existing designs for optimizing the dose combination are model-based, requiring significant effor...

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Detalles Bibliográficos
Autores principales: Zhang, Jingyi, Yan, Fangrong, Wages, Nolan A, Lin, Ruitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563380/
https://www.ncbi.nlm.nih.gov/pubmed/37593951
http://dx.doi.org/10.1177/09622802231192955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563380/
https://www.ncbi.nlm.nih.gov/pubmed/37593951
http://dx.doi.org/10.1177/09622802231192955

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