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Local continual reassessment methods for dose finding and optimization in drug-combination trials
Due to the limited sample size and large dose exploration space, obtaining a desirable dose combination is a challenging task in the early development of combination treatments for cancer patients. Most existing designs for optimizing the dose combination are model-based, requiring significant effor...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
SAGE Publications
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563380/ https://www.ncbi.nlm.nih.gov/pubmed/37593951 http://dx.doi.org/10.1177/09622802231192955 |