Anti-GARP Antibodies Inhibit Release of TGF-β by Regulatory T Cells via Different Modes of Action, but Do Not Influence Their Function In Vitro

Regulatory T cells (Treg) play a critical role in controlling immune responses in diseases such as cancer or autoimmunity. Activated Treg express the membrane protein GARP (LRRC32) in complex with the latent form of the immunosuppressive cytokine TGF-β (L-TGF-β). In this study, we confirmed that act...

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Detalles Bibliográficos
Autores principales: Igney, Frederik H., Ebenhoch, Rebecca, Schiele, Felix, Nar, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2023
Materias:
Adaptive Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563435/
https://www.ncbi.nlm.nih.gov/pubmed/36928178
http://dx.doi.org/10.4049/immunohorizons.2200072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563435/
https://www.ncbi.nlm.nih.gov/pubmed/36928178
http://dx.doi.org/10.4049/immunohorizons.2200072

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