Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly

KEAP1 promotes the ubiquitin-dependent degradation of NRF2 by assembling into a CUL3-dependent ubiquitin ligase complex. Oxidative and electrophilic stress inhibit KEAP1 allowing NRF2 to accumulate for the transactivation of stress response genes. To date there are no structures of the KEAP1-CUL3 in...

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Detalles Bibliográficos
Autores principales: Adamson, Roslin J., Payne, N Connor, Bartual, Sergio G., Mazitschek, Ralph, Bullock, Alex N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564622/
https://www.ncbi.nlm.nih.gov/pubmed/37156295
http://dx.doi.org/10.1016/j.freeradbiomed.2023.04.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564622/
https://www.ncbi.nlm.nih.gov/pubmed/37156295
http://dx.doi.org/10.1016/j.freeradbiomed.2023.04.021

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