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Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly
KEAP1 promotes the ubiquitin-dependent degradation of NRF2 by assembling into a CUL3-dependent ubiquitin ligase complex. Oxidative and electrophilic stress inhibit KEAP1 allowing NRF2 to accumulate for the transactivation of stress response genes. To date there are no structures of the KEAP1-CUL3 in...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564622/ https://www.ncbi.nlm.nih.gov/pubmed/37156295 http://dx.doi.org/10.1016/j.freeradbiomed.2023.04.021 |