Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2

The Src homology 2 (SH2) domain recognizes phosphotyrosine (pY) post translational modifications in partner proteins to trigger downstream signaling. Drug discovery efforts targeting the SH2 domains have long been stymied by the poor drug-like properties of phosphate and its mimetics. Here, we use s...

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Detalles Bibliográficos
Autores principales: Ramachandran, Sarath, Makukhin, Nikolai, Haubrich, Kevin, Nagala, Manjula, Forrester, Beth, Lynch, Dylan M., Casement, Ryan, Testa, Andrea, Bruno, Elvira, Gitto, Rosaria, Ciulli, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564737/
https://www.ncbi.nlm.nih.gov/pubmed/37816714
http://dx.doi.org/10.1038/s41467-023-41894-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564737/
https://www.ncbi.nlm.nih.gov/pubmed/37816714
http://dx.doi.org/10.1038/s41467-023-41894-3

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