Solubility measurement of verapamil for the preparation of developed nanomedicines using supercritical fluid

A static method is employed to determine the solubilities of verapamil in supercritical carbon dioxide (SC-CO(2)) at temperatures between 308 and 338 K and pressures between 12 and 30 MPa. The solubility of verapamil in SC-CO(2) expressed as mole fraction are in the range of 3.6 × 10(–6) to 7.14 × 1...

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Autores principales: Esfandiari, Nadia, Saadati Ardestani, Nedasadat, Alwi, Ratna Surya, Rojas, Adrián, Garlapati, Chandrasekhar, Sajadian, Seyed Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564778/
https://www.ncbi.nlm.nih.gov/pubmed/37816767
http://dx.doi.org/10.1038/s41598-023-44280-7
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author Esfandiari, Nadia
Saadati Ardestani, Nedasadat
Alwi, Ratna Surya
Rojas, Adrián
Garlapati, Chandrasekhar
Sajadian, Seyed Ali
author_facet Esfandiari, Nadia
Saadati Ardestani, Nedasadat
Alwi, Ratna Surya
Rojas, Adrián
Garlapati, Chandrasekhar
Sajadian, Seyed Ali
author_sort Esfandiari, Nadia
collection PubMed
description A static method is employed to determine the solubilities of verapamil in supercritical carbon dioxide (SC-CO(2)) at temperatures between 308 and 338 K and pressures between 12 and 30 MPa. The solubility of verapamil in SC-CO(2) expressed as mole fraction are in the range of 3.6 × 10(–6) to 7.14 × 10(–5). Using four semi-empirical density-based models, the solubility data are correlated: Chrastil, Bartle, Kumar–Johnston (K–J), and Mendez-Santiago and Teja (MST), two equations of state (SRK and PC-SAFT EoS), expanded liquid models (modified Wilson's models), and regular solution model. The obtained results indicated that the regular solution and PC-SAFT models showed the most noteworthy exactness with AARD% of 1.68 and 7.45, respectively. The total heat, vaporization heat, and solvation heat of verapamil are calculated at 39.62, 60.03, and − 20.41 kJ/mol, respectively. Regarding the poor solubility of verapamil in SC-CO(2), supercritical anti-solvent methods can be an appropriate choice to produce fine particles of this drug.
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spelling pubmed-105647782023-10-12 Solubility measurement of verapamil for the preparation of developed nanomedicines using supercritical fluid Esfandiari, Nadia Saadati Ardestani, Nedasadat Alwi, Ratna Surya Rojas, Adrián Garlapati, Chandrasekhar Sajadian, Seyed Ali Sci Rep Article A static method is employed to determine the solubilities of verapamil in supercritical carbon dioxide (SC-CO(2)) at temperatures between 308 and 338 K and pressures between 12 and 30 MPa. The solubility of verapamil in SC-CO(2) expressed as mole fraction are in the range of 3.6 × 10(–6) to 7.14 × 10(–5). Using four semi-empirical density-based models, the solubility data are correlated: Chrastil, Bartle, Kumar–Johnston (K–J), and Mendez-Santiago and Teja (MST), two equations of state (SRK and PC-SAFT EoS), expanded liquid models (modified Wilson's models), and regular solution model. The obtained results indicated that the regular solution and PC-SAFT models showed the most noteworthy exactness with AARD% of 1.68 and 7.45, respectively. The total heat, vaporization heat, and solvation heat of verapamil are calculated at 39.62, 60.03, and − 20.41 kJ/mol, respectively. Regarding the poor solubility of verapamil in SC-CO(2), supercritical anti-solvent methods can be an appropriate choice to produce fine particles of this drug. Nature Publishing Group UK 2023-10-10 /pmc/articles/PMC10564778/ /pubmed/37816767 http://dx.doi.org/10.1038/s41598-023-44280-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Esfandiari, Nadia
Saadati Ardestani, Nedasadat
Alwi, Ratna Surya
Rojas, Adrián
Garlapati, Chandrasekhar
Sajadian, Seyed Ali
Solubility measurement of verapamil for the preparation of developed nanomedicines using supercritical fluid
title Solubility measurement of verapamil for the preparation of developed nanomedicines using supercritical fluid
title_full Solubility measurement of verapamil for the preparation of developed nanomedicines using supercritical fluid
title_fullStr Solubility measurement of verapamil for the preparation of developed nanomedicines using supercritical fluid
title_full_unstemmed Solubility measurement of verapamil for the preparation of developed nanomedicines using supercritical fluid
title_short Solubility measurement of verapamil for the preparation of developed nanomedicines using supercritical fluid
title_sort solubility measurement of verapamil for the preparation of developed nanomedicines using supercritical fluid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564778/
https://www.ncbi.nlm.nih.gov/pubmed/37816767
http://dx.doi.org/10.1038/s41598-023-44280-7
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