NAT10-dependent N(4)‐acetylcytidine modification mediates PAN RNA stability, KSHV reactivation, and IFI16-related inflammasome activation

N-acetyltransferase 10 (NAT10) is an N(4)‐acetylcytidine (ac(4)C) writer that catalyzes RNA acetylation at cytidine N(4) position on tRNAs, rRNAs and mRNAs. Recently, NAT10 and the associated ac(4)C have been reported to increase the stability of HIV-1 transcripts. Here, we show that NAT10 catalyzes...

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Detalles Bibliográficos
Autores principales: Yan, Qin, Zhou, Jing, Wang, Ziyu, Ding, Xiangya, Ma, Xinyue, Li, Wan, Jia, Xuemei, Gao, Shou-Jiang, Lu, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564894/
https://www.ncbi.nlm.nih.gov/pubmed/37816771
http://dx.doi.org/10.1038/s41467-023-42135-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564894/
https://www.ncbi.nlm.nih.gov/pubmed/37816771
http://dx.doi.org/10.1038/s41467-023-42135-3

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