Downregulation of EphA2 stability by RNF5 limits its tumor-suppressive function in HER2-negative breast cancers

Ephrin receptor A2 (EphA2) plays dual functions in tumorigenesis through ligand-independent tumor promotion or ligand-dependent tumor suppression. However, the regulation of EphA2 tumor-suppressive function remains unclear. Here, we showed that RNF5 interacts with EphA2 and induces its ubiquitinatio...

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Detalles Bibliográficos
Autores principales: Li, Xiaojuan, Wang, Fan, Huang, Lu, Yang, Mengtian, Kuang, Ersheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564927/
https://www.ncbi.nlm.nih.gov/pubmed/37816703
http://dx.doi.org/10.1038/s41419-023-06188-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564927/
https://www.ncbi.nlm.nih.gov/pubmed/37816703
http://dx.doi.org/10.1038/s41419-023-06188-y

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