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Downregulation of EphA2 stability by RNF5 limits its tumor-suppressive function in HER2-negative breast cancers
Ephrin receptor A2 (EphA2) plays dual functions in tumorigenesis through ligand-independent tumor promotion or ligand-dependent tumor suppression. However, the regulation of EphA2 tumor-suppressive function remains unclear. Here, we showed that RNF5 interacts with EphA2 and induces its ubiquitinatio...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564927/ https://www.ncbi.nlm.nih.gov/pubmed/37816703 http://dx.doi.org/10.1038/s41419-023-06188-y |