Founder population-specific weights yield improvements in performance of polygenic risk scores for Alzheimer disease in the Midwestern Amish

Alzheimer disease (AD) is the most common type of dementia and is estimated to affect 6 million Americans. Risk for AD is multifactorial, including both genetic and environmental risk factors. AD genomic research has generally focused on identification of risk variants. Using this information, polyg...

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Detalles Bibliográficos
Autores principales: Osterman, Michael D., Song, Yeunjoo E., Lynn, Audrey, Miskimen, Kristy, Adams, Larry D., Laux, Renee A., Caywood, Laura J., Prough, Michael B., Clouse, Jason E., Herington, Sharlene D., Slifer, Susan H., Fuzzell, Sarada L., Hochstetler, Sherri D., Main, Leighanne R., Dorfsman, Daniel A., Zaman, Andrew F., Ogrocki, Paula, Lerner, Alan J., Vance, Jeffery M., Cuccaro, Michael L., Scott, William K., Pericak-Vance, Margaret A., Haines, Jonathan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565871/
https://www.ncbi.nlm.nih.gov/pubmed/37742071
http://dx.doi.org/10.1016/j.xhgg.2023.100241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565871/
https://www.ncbi.nlm.nih.gov/pubmed/37742071
http://dx.doi.org/10.1016/j.xhgg.2023.100241

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