Obesity drives adipose-derived stem cells into a senescent and dysfunctional phenotype associated with P38MAPK/NF-KB axis

BACKGROUND: Adipose-derived stem cells (ADSC) are multipotent cells implicated in tissue homeostasis. Obesity represents a chronic inflammatory disease associated with metabolic dysfunction and age-related mechanisms, with progressive accumulation of senescent cells and compromised ADSC function. In...

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Detalles Bibliográficos
Autores principales: Grun, L K, Maurmann, R M, Scholl, J N, Fogaça, M E, Schmitz, C R R, Dias, C K, Gasparotto, J, Padoin, A V, Mottin, C C, Klamt, F, Figueiró, F, Jones, M H, Filippi-Chiela, E C, Guma, F C R, Barbé-Tuana, F M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566105/
https://www.ncbi.nlm.nih.gov/pubmed/37821967
http://dx.doi.org/10.1186/s12979-023-00378-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566105/
https://www.ncbi.nlm.nih.gov/pubmed/37821967
http://dx.doi.org/10.1186/s12979-023-00378-0

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