Early developmental deletion of forebrain Ank2 causes seizure-related phenotypes by reshaping the synaptic proteome

Rare genetic variants in ANK2, which encodes ankyrin-B, are associated with neurodevelopmental disorders (NDDs); however, their pathogenesis is poorly understood. We find that mice with prenatal deletion in cortical excitatory neurons and oligodendrocytes (ANK2(−/−):Emx1-Cre), but not with adolescen...

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Detalles Bibliográficos
Autores principales: Yoon, Sehyoun, Dos Santos, Marc, Forrest, Marc P., Pratt, Christopher P., Khalatyan, Natalia, Mohler, Peter J., Savas, Jeffrey N., Penzes, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566302/
https://www.ncbi.nlm.nih.gov/pubmed/37428632
http://dx.doi.org/10.1016/j.celrep.2023.112784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566302/
https://www.ncbi.nlm.nih.gov/pubmed/37428632
http://dx.doi.org/10.1016/j.celrep.2023.112784

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