Gad1 knock-out rats exhibit abundant spike-wave discharges in EEG, exacerbated with valproate treatment

OBJECTIVE: To elucidate the functional role of gamma-aminobutyric acid (GABA)-ergic inhibition in suppressing epileptic brain activities such as spike-wave discharge (SWD), we recorded electroencephalogram (EEG) in knockout rats for Glutamate decarboxylase 1 (Gad1), which encodes one of the two GABA...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Dongyu, Fujihara, Kazuyuki, Yanagawa, Yuchio, Mushiake, Hajime, Ohshiro, Tomokazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566305/
https://www.ncbi.nlm.nih.gov/pubmed/37830095
http://dx.doi.org/10.3389/fneur.2023.1243301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566305/
https://www.ncbi.nlm.nih.gov/pubmed/37830095
http://dx.doi.org/10.3389/fneur.2023.1243301

Ejemplares similares