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Gad1 knock-out rats exhibit abundant spike-wave discharges in EEG, exacerbated with valproate treatment

OBJECTIVE: To elucidate the functional role of gamma-aminobutyric acid (GABA)-ergic inhibition in suppressing epileptic brain activities such as spike-wave discharge (SWD), we recorded electroencephalogram (EEG) in knockout rats for Glutamate decarboxylase 1 (Gad1), which encodes one of the two GABA...

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Detalles Bibliográficos
Autores principales:	Liu, Dongyu, Fujihara, Kazuyuki, Yanagawa, Yuchio, Mushiake, Hajime, Ohshiro, Tomokazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Neurology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566305/ https://www.ncbi.nlm.nih.gov/pubmed/37830095 http://dx.doi.org/10.3389/fneur.2023.1243301

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