General acid-mediated aminolactone formation using unactivated alkenes

Spirocyclic butyrolactones and butenolides are widespread structural motifs in bioactive substances. Despite their prevalence, a simple method ensuring their direct preparation from exocyclic alkenes, ideally in a late-stage context, remains elusive. Herein, we report direct aminolactone formation u...

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Detalles Bibliográficos
Autores principales: Just, David, Gonçalves, Carlos R., Vezonik, Uroš, Kaiser, Daniel, Maulide, Nuno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566462/
https://www.ncbi.nlm.nih.gov/pubmed/37829023
http://dx.doi.org/10.1039/d3sc04073a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566462/
https://www.ncbi.nlm.nih.gov/pubmed/37829023
http://dx.doi.org/10.1039/d3sc04073a

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