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A tunable family of CAAC-ruthenium olefin metathesis catalysts modularly derived from a large-scale produced ibuprofen intermediate

A series of tunable CAAC-based ruthenium benzylidene complexes with increased lipophilicity derived from a ketone being a large-scale produced key substrate for a popular nonsteroidal anti-inflammatory drug—ibuprofen was obtained and tested in various olefin metathesis transformations. As a group, t...

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Detalles Bibliográficos
Autores principales: Sytniczuk, Adrian, Struzik, Filip, Grela, Karol, Kajetanowicz, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566500/
https://www.ncbi.nlm.nih.gov/pubmed/37829018
http://dx.doi.org/10.1039/d3sc03849a