Masked cerulenin enables a dual-site selective protein crosslink

Protein-reactive natural products such as the fungal metabolite cerulenin are recognized for their value as therapeutic candidates, due to their ability to selectively react with catalytic residues within a protein active site or a complex of protein domains. Here, we explore the development of fatt...

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Detalles Bibliográficos
Autores principales: Jiang, Ziran, Chen, Aochiu, Chen, Jeffrey, Sekhon, Arman, Louie, Gordon V., Noel, Joseph P., La Clair, James J., Burkart, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566503/
https://www.ncbi.nlm.nih.gov/pubmed/37829009
http://dx.doi.org/10.1039/d3sc02864j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566503/
https://www.ncbi.nlm.nih.gov/pubmed/37829009
http://dx.doi.org/10.1039/d3sc02864j

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