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Masked cerulenin enables a dual-site selective protein crosslink
Protein-reactive natural products such as the fungal metabolite cerulenin are recognized for their value as therapeutic candidates, due to their ability to selectively react with catalytic residues within a protein active site or a complex of protein domains. Here, we explore the development of fatt...
Autores principales: | Jiang, Ziran, Chen, Aochiu, Chen, Jeffrey, Sekhon, Arman, Louie, Gordon V., Noel, Joseph P., La Clair, James J., Burkart, Michael D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566503/ https://www.ncbi.nlm.nih.gov/pubmed/37829009 http://dx.doi.org/10.1039/d3sc02864j |
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