Adenylosuccinate lyase deficiency affects neurobehavior via perturbations to tyramine signaling in Caenorhabditis elegans

Adenylosuccinate lyase deficiency is an ultrarare congenital metabolic disorder associated with muscle weakness and neurobehavioral dysfunction. Adenylosuccinate lyase is required for de novo purine biosynthesis, acting twice in the pathway at non-sequential steps. Genetic models can contribute to o...

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Detalles Bibliográficos
Autores principales: Moro, Corinna A., Sony, Sabrina A., Franklin, Latisha P., Dong, Shirley, Peifer, Mia M., Wittig, Kathryn E., Hanna-Rose, Wendy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566684/
https://www.ncbi.nlm.nih.gov/pubmed/37773959
http://dx.doi.org/10.1371/journal.pgen.1010974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566684/
https://www.ncbi.nlm.nih.gov/pubmed/37773959
http://dx.doi.org/10.1371/journal.pgen.1010974

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