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The effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester–A primary cohort study with a scoping review

INTRODUCTION: Supine sleep position is associated with stillbirth, likely secondary to inferior vena cava compression, and a reduction in cardiac output (CO) and uteroplacental perfusion. Evidence for the effects of prone position in pregnancy is less clear. This study aimed to determine the effect...

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Autores principales: Ormesher, Laura, Catchpole, Jessica, Peacock, Linda, Pitt, Heather, Fabian-Hunt, Anastasia, Hayes, Dexter, Popp, Claudia, Carson, Jason M., van Loon, Raoul, Warrander, Lynne, Büchling, Karli, Heazell, Alexander E. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566740/
https://www.ncbi.nlm.nih.gov/pubmed/37819872
http://dx.doi.org/10.1371/journal.pone.0287804
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author Ormesher, Laura
Catchpole, Jessica
Peacock, Linda
Pitt, Heather
Fabian-Hunt, Anastasia
Hayes, Dexter
Popp, Claudia
Carson, Jason M.
van Loon, Raoul
Warrander, Lynne
Büchling, Karli
Heazell, Alexander E. P.
author_facet Ormesher, Laura
Catchpole, Jessica
Peacock, Linda
Pitt, Heather
Fabian-Hunt, Anastasia
Hayes, Dexter
Popp, Claudia
Carson, Jason M.
van Loon, Raoul
Warrander, Lynne
Büchling, Karli
Heazell, Alexander E. P.
author_sort Ormesher, Laura
collection PubMed
description INTRODUCTION: Supine sleep position is associated with stillbirth, likely secondary to inferior vena cava compression, and a reduction in cardiac output (CO) and uteroplacental perfusion. Evidence for the effects of prone position in pregnancy is less clear. This study aimed to determine the effect maternal prone position on maternal haemodynamics and fetal heart rate, compared with left lateral position. METHODS: Twenty-one women >28 weeks’ gestation underwent non-invasive CO monitoring (Cheetah) every 5 minutes and continuous fetal heart rate monitoring (MONICA) in left lateral (20 minutes), prone (30 minutes), followed by left lateral (20 minutes). Anxiety and comfort were assessed by questionnaires. Regression analyses (adjusted for time) compared variables between positions. The information derived from the primary study was used in an existing mathematical model of maternal circulation in pregnancy, to determine whether occlusion of the inferior vena cava could account for the observed effects. In addition, a scoping review was performed to identify reported clinical, haemodynamic and fetal effects of maternal prone position; studies were included if they reported clinical outcomes or effects or maternal prone position in pregnancy. Study records were grouped by publication type for ease of data synthesis and critical analysis. Meta-analysis was performed where there were sufficient studies. RESULTS: Maternal blood pressure (BP) and total vascular resistance (TVR) were increased in prone (sBP 109 vs 104 mmHg, p = 0.03; dBP 74 vs 67 mmHg, p = 0.003; TVR 1302 vs 1075 dyne.s-1cm-5, p = 0.03). CO was reduced in prone (5.7 vs 7.1 mL/minute, p = 0.003). Fetal heart rate, variability and decelerations were unaltered. However, fetal accelerations were less common in prone position (86% vs 95%, p = 0.03). Anxiety was reduced after the procedure, compared to beforehand (p = 0.002), despite a marginal decline in comfort (p = 0.04).The model predicted that if occlusion of the inferior vena cava occurred, the sBP, dBP and CO would generally decrease. However, the TVR remained relatively consistent, which implies that the MAP and CO decrease at a similar rate when occlusion occurs. The scoping review found that maternal and fetal outcomes from 47 included case reports of prone positioning during pregnancy were generally favourable. Meta-analysis of three prospective studies investigating maternal haemodynamic effects of prone position found an increase in sBP and maternal heart rate, but no effect on respiratory rate, oxygen saturation or baseline fetal heart rate (though there was significant heterogeneity between studies). CONCLUSION: Prone position was associated with a reduction in CO but an uncertain effect on fetal wellbeing. The decline in CO may be due to caval compression, as supported by the computational model. Further work is needed to optimise the safety of prone positioning in pregnancy. TRIAL REGISTRATION: This trial was registered at clinicaltrials.gov (NCT04586283).
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spelling pubmed-105667402023-10-12 The effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester–A primary cohort study with a scoping review Ormesher, Laura Catchpole, Jessica Peacock, Linda Pitt, Heather Fabian-Hunt, Anastasia Hayes, Dexter Popp, Claudia Carson, Jason M. van Loon, Raoul Warrander, Lynne Büchling, Karli Heazell, Alexander E. P. PLoS One Research Article INTRODUCTION: Supine sleep position is associated with stillbirth, likely secondary to inferior vena cava compression, and a reduction in cardiac output (CO) and uteroplacental perfusion. Evidence for the effects of prone position in pregnancy is less clear. This study aimed to determine the effect maternal prone position on maternal haemodynamics and fetal heart rate, compared with left lateral position. METHODS: Twenty-one women >28 weeks’ gestation underwent non-invasive CO monitoring (Cheetah) every 5 minutes and continuous fetal heart rate monitoring (MONICA) in left lateral (20 minutes), prone (30 minutes), followed by left lateral (20 minutes). Anxiety and comfort were assessed by questionnaires. Regression analyses (adjusted for time) compared variables between positions. The information derived from the primary study was used in an existing mathematical model of maternal circulation in pregnancy, to determine whether occlusion of the inferior vena cava could account for the observed effects. In addition, a scoping review was performed to identify reported clinical, haemodynamic and fetal effects of maternal prone position; studies were included if they reported clinical outcomes or effects or maternal prone position in pregnancy. Study records were grouped by publication type for ease of data synthesis and critical analysis. Meta-analysis was performed where there were sufficient studies. RESULTS: Maternal blood pressure (BP) and total vascular resistance (TVR) were increased in prone (sBP 109 vs 104 mmHg, p = 0.03; dBP 74 vs 67 mmHg, p = 0.003; TVR 1302 vs 1075 dyne.s-1cm-5, p = 0.03). CO was reduced in prone (5.7 vs 7.1 mL/minute, p = 0.003). Fetal heart rate, variability and decelerations were unaltered. However, fetal accelerations were less common in prone position (86% vs 95%, p = 0.03). Anxiety was reduced after the procedure, compared to beforehand (p = 0.002), despite a marginal decline in comfort (p = 0.04).The model predicted that if occlusion of the inferior vena cava occurred, the sBP, dBP and CO would generally decrease. However, the TVR remained relatively consistent, which implies that the MAP and CO decrease at a similar rate when occlusion occurs. The scoping review found that maternal and fetal outcomes from 47 included case reports of prone positioning during pregnancy were generally favourable. Meta-analysis of three prospective studies investigating maternal haemodynamic effects of prone position found an increase in sBP and maternal heart rate, but no effect on respiratory rate, oxygen saturation or baseline fetal heart rate (though there was significant heterogeneity between studies). CONCLUSION: Prone position was associated with a reduction in CO but an uncertain effect on fetal wellbeing. The decline in CO may be due to caval compression, as supported by the computational model. Further work is needed to optimise the safety of prone positioning in pregnancy. TRIAL REGISTRATION: This trial was registered at clinicaltrials.gov (NCT04586283). Public Library of Science 2023-10-11 /pmc/articles/PMC10566740/ /pubmed/37819872 http://dx.doi.org/10.1371/journal.pone.0287804 Text en © 2023 Ormesher et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ormesher, Laura
Catchpole, Jessica
Peacock, Linda
Pitt, Heather
Fabian-Hunt, Anastasia
Hayes, Dexter
Popp, Claudia
Carson, Jason M.
van Loon, Raoul
Warrander, Lynne
Büchling, Karli
Heazell, Alexander E. P.
The effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester–A primary cohort study with a scoping review
title The effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester–A primary cohort study with a scoping review
title_full The effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester–A primary cohort study with a scoping review
title_fullStr The effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester–A primary cohort study with a scoping review
title_full_unstemmed The effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester–A primary cohort study with a scoping review
title_short The effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester–A primary cohort study with a scoping review
title_sort effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester–a primary cohort study with a scoping review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566740/
https://www.ncbi.nlm.nih.gov/pubmed/37819872
http://dx.doi.org/10.1371/journal.pone.0287804
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