Adapting Neutralizing Antibodies to Viral Variants by Structure‐Guided Affinity Maturation Using Phage Display Technology

Neutralizing monoclonal antibodies have achieved great efficacy and safety for the treatment of numerous infectious diseases. However, their neutralization potency is often rapidly lost when the target antigen mutates. Instead of isolating new antibodies each time a pathogen variant arises, it can b...

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Detalles Bibliográficos
Autores principales: Peissert, Frederik, Pedotti, Mattia, Corbellari, Riccardo, Simonelli, Luca, De Gasparo, Raoul, Tamagnini, Elia, Plüss, Louis, Elsayed, Abdullah, Matasci, Mattia, De Luca, Roberto, Cassaniti, Irene, Sammartino, Jose’ Camilla, Piralla, Antonio, Baldanti, Fausto, Neri, Dario, Varani, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566804/
https://www.ncbi.nlm.nih.gov/pubmed/37829677
http://dx.doi.org/10.1002/gch2.202300088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566804/
https://www.ncbi.nlm.nih.gov/pubmed/37829677
http://dx.doi.org/10.1002/gch2.202300088

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