GDF15 is required for cold-induced thermogenesis and contributes to improved systemic metabolic health following loss of OPA1 in brown adipocytes

We previously reported that mice lacking the protein optic atrophy 1 (OPA1 BKO) in brown adipose tissue (BAT) display induction of the activating transcription factor 4 (ATF4), which promotes fibroblast growth factor 21 (FGF21) secretion as a batokine. FGF21 increases metabolic rates under baseline...

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Detalles Bibliográficos
Autores principales: Jena, Jayashree, García-Peña, Luis Miguel, Weatherford, Eric T, Marti, Alex, Bjorkman, Sarah H, Kato, Kevin, Koneru, Jivan, Chen, Jason H, Seeley, Randy J, Abel, E Dale, Pereira, Renata O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567111/
https://www.ncbi.nlm.nih.gov/pubmed/37819027
http://dx.doi.org/10.7554/eLife.86452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567111/
https://www.ncbi.nlm.nih.gov/pubmed/37819027
http://dx.doi.org/10.7554/eLife.86452

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