RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy

TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by aggregation and mislocalization of the nucleic acid-binding protein TDP-43 and subsequent neuronal dysfunction. Here, we developed endoge...

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Detalles Bibliográficos
Autores principales: Necarsulmer, Julie C, Simon, Jeremy M, Evangelista, Baggio A, Chen, Youjun, Tian, Xu, Nafees, Sara, Marquez, Ariana B, Jiang, Huijun, Wang, Ping, Ajit, Deepa, Nikolova, Viktoriya D, Harper, Kathryn M, Ezzell, J Ashley, Lin, Feng-Chang, Beltran, Adriana S, Moy, Sheryl S, Cohen, Todd J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567115/
https://www.ncbi.nlm.nih.gov/pubmed/37819053
http://dx.doi.org/10.7554/eLife.85921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567115/
https://www.ncbi.nlm.nih.gov/pubmed/37819053
http://dx.doi.org/10.7554/eLife.85921

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