Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants

Most short sequences can be precisely written into a selected genomic target using prime editing; however, it remains unclear what factors govern insertion. We design a library of 3,604 sequences of various lengths and measure the frequency of their insertion into four genomic sites in three human c...

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Detalles Bibliográficos
Autores principales: Koeppel, Jonas, Weller, Juliane, Peets, Elin Madli, Pallaseni, Ananth, Kuzmin, Ivan, Raudvere, Uku, Peterson, Hedi, Liberante, Fabio Giuseppe, Parts, Leopold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567557/
https://www.ncbi.nlm.nih.gov/pubmed/36797492
http://dx.doi.org/10.1038/s41587-023-01678-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567557/
https://www.ncbi.nlm.nih.gov/pubmed/36797492
http://dx.doi.org/10.1038/s41587-023-01678-y

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