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Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants
Most short sequences can be precisely written into a selected genomic target using prime editing; however, it remains unclear what factors govern insertion. We design a library of 3,604 sequences of various lengths and measure the frequency of their insertion into four genomic sites in three human c...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567557/ https://www.ncbi.nlm.nih.gov/pubmed/36797492 http://dx.doi.org/10.1038/s41587-023-01678-y |