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Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment
The assembly of cortical circuits involves the generation and migration of interneurons from the ventral to the dorsal forebrain(1–3), which has been challenging to study at inaccessible stages of late gestation and early postnatal human development(4). Autism spectrum disorder and other neurodevelo...
Autores principales: | Meng, Xiangling, Yao, David, Imaizumi, Kent, Chen, Xiaoyu, Kelley, Kevin W., Reis, Noah, Thete, Mayuri Vijay, Arjun McKinney, Arpana, Kulkarni, Shravanti, Panagiotakos, Georgia, Bassik, Michael C., Pașca, Sergiu P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567561/ https://www.ncbi.nlm.nih.gov/pubmed/37758944 http://dx.doi.org/10.1038/s41586-023-06564-w |
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