Transcriptional linkage analysis with in vivo AAV-Perturb-seq

The ever-growing compendium of genetic variants associated with human pathologies demands new methods to study genotype–phenotype relationships in complex tissues in a high-throughput manner(1,2). Here we introduce adeno-associated virus (AAV)-mediated direct in vivo single-cell CRISPR screening, te...

Descripción completa

Detalles Bibliográficos
Autores principales: Santinha, Antonio J., Klingler, Esther, Kuhn, Maria, Farouni, Rick, Lagler, Sandra, Kalamakis, Georgios, Lischetti, Ulrike, Jabaudon, Denis, Platt, Randall J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567566/
https://www.ncbi.nlm.nih.gov/pubmed/37730998
http://dx.doi.org/10.1038/s41586-023-06570-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567566/
https://www.ncbi.nlm.nih.gov/pubmed/37730998
http://dx.doi.org/10.1038/s41586-023-06570-y

Ejemplares similares