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Transcriptional linkage analysis with in vivo AAV-Perturb-seq

The ever-growing compendium of genetic variants associated with human pathologies demands new methods to study genotype–phenotype relationships in complex tissues in a high-throughput manner(1,2). Here we introduce adeno-associated virus (AAV)-mediated direct in vivo single-cell CRISPR screening, te...

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Detalles Bibliográficos
Autores principales:	Santinha, Antonio J., Klingler, Esther, Kuhn, Maria, Farouni, Rick, Lagler, Sandra, Kalamakis, Georgios, Lischetti, Ulrike, Jabaudon, Denis, Platt, Randall J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567566/ https://www.ncbi.nlm.nih.gov/pubmed/37730998 http://dx.doi.org/10.1038/s41586-023-06570-y

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