Defining E3 ligase–substrate relationships through multiplex CRISPR screening

Specificity within the ubiquitin–proteasome system is primarily achieved through E3 ubiquitin ligases, but for many E3s their substrates—and in particular the molecular features (degrons) that they recognize—remain largely unknown. Current approaches for assigning E3s to their cognate substrates are...

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Detalles Bibliográficos
Autores principales: Timms, Richard T., Mena, Elijah L., Leng, Yumei, Li, Mamie Z., Tchasovnikarova, Iva A., Koren, Itay, Elledge, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Technical Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567573/
https://www.ncbi.nlm.nih.gov/pubmed/37735597
http://dx.doi.org/10.1038/s41556-023-01229-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567573/
https://www.ncbi.nlm.nih.gov/pubmed/37735597
http://dx.doi.org/10.1038/s41556-023-01229-2

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