Relationship among DDR gene mutations, TMB and PD-L1 in solid tumour genomes identified using clinically actionable biomarker assays

The DNA damage response (DDR) pathway regulates DNA repair and cell survival, and inactivating mutations in DDR genes can increase tumour mutational burden (TMB), a predictive biomarker of treatment benefit from anti-PD-1/PD-L1 immunotherapies. However, a better understanding of the relationship amo...

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Detalles Bibliográficos
Autores principales: Wang, Danyi, Elenbaas, Brian, Murugesan, Karthikeyan, Shah, Kunal, Montesion, Meagan, Gounaris, Ioannis, Scheuenpflug, Juergen, Locatelli, Giuseppe, Feng, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567713/
https://www.ncbi.nlm.nih.gov/pubmed/37821580
http://dx.doi.org/10.1038/s41698-023-00442-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567713/
https://www.ncbi.nlm.nih.gov/pubmed/37821580
http://dx.doi.org/10.1038/s41698-023-00442-4

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