Structural basis of promiscuous substrate transport by Organic Cation Transporter 1

Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by mediating the uptake of a range of metabolites and drugs. Genetic variations can alter the efficacy and safety of compounds transported by OCT1, such as those used for cardiovascular, oncological, and psychological ind...

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Detalles Bibliográficos
Autores principales: Zeng, Yi C., Sobti, Meghna, Quinn, Ada, Smith, Nicola J., Brown, Simon H. J., Vandenberg, Jamie I., Ryan, Renae M., O’Mara, Megan L., Stewart, Alastair G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567722/
https://www.ncbi.nlm.nih.gov/pubmed/37821493
http://dx.doi.org/10.1038/s41467-023-42086-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567722/
https://www.ncbi.nlm.nih.gov/pubmed/37821493
http://dx.doi.org/10.1038/s41467-023-42086-9

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