Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo

Cobalamin-dependent methionine synthase (MS) is a key enzyme in methionine and folate one-carbon metabolism. MS is a large multi-domain protein capable of binding and activating three substrates: homocysteine, folate, and S-adenosylmethionine for methylation. Achieving three chemically distinct meth...

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Detalles Bibliográficos
Autores principales: Mendoza, Johnny, Purchal, Meredith, Yamada, Kazuhiro, Koutmos, Markos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567725/
https://www.ncbi.nlm.nih.gov/pubmed/37821448
http://dx.doi.org/10.1038/s41467-023-42037-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567725/
https://www.ncbi.nlm.nih.gov/pubmed/37821448
http://dx.doi.org/10.1038/s41467-023-42037-4

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