C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy

The multi-subunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for autophagosome-lysosome fusion in mammals, yet reconstituting the mammalian HOPS complex remains a challenge. Here we propose a “hook-up” model for mammalian HOPS complex assembly, which r...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Shen, Tong, Mindan, Zheng, Denghao, Huang, Huiying, Li, Linsen, Ungermann, Christian, Pan, Yi, Luo, Hanyan, Lei, Ming, Tang, Zaiming, Fu, Wan, Chen, She, Liu, Xiaoxia, Zhong, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567733/
https://www.ncbi.nlm.nih.gov/pubmed/37821429
http://dx.doi.org/10.1038/s41467-023-42003-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567733/
https://www.ncbi.nlm.nih.gov/pubmed/37821429
http://dx.doi.org/10.1038/s41467-023-42003-0

Ejemplares similares