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C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy

The multi-subunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for autophagosome-lysosome fusion in mammals, yet reconstituting the mammalian HOPS complex remains a challenge. Here we propose a “hook-up” model for mammalian HOPS complex assembly, which r...

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Detalles Bibliográficos
Autores principales:	Zhang, Shen, Tong, Mindan, Zheng, Denghao, Huang, Huiying, Li, Linsen, Ungermann, Christian, Pan, Yi, Luo, Hanyan, Lei, Ming, Tang, Zaiming, Fu, Wan, Chen, She, Liu, Xiaoxia, Zhong, Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567733/ https://www.ncbi.nlm.nih.gov/pubmed/37821429 http://dx.doi.org/10.1038/s41467-023-42003-0

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