Slack K(+) channels limit kainic acid-induced seizure severity in mice by modulating neuronal excitability and firing

Mutations of the Na(+)-activated K(+) channel Slack (KCNT1) are associated with terrible epilepsy syndromes that already begin in infancy. Here we report increased severity of acute kainic acid-induced seizures in adult and juvenile Slack knockout mice (Slack(−/−)) in vivo. Fittingly, we find exacer...

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Detalles Bibliográficos
Autores principales: Skrabak, David, Bischof, Helmut, Pham, Thomas, Ruth, Peter, Ehinger, Rebekka, Matt, Lucas, Lukowski, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567740/
https://www.ncbi.nlm.nih.gov/pubmed/37821582
http://dx.doi.org/10.1038/s42003-023-05387-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567740/
https://www.ncbi.nlm.nih.gov/pubmed/37821582
http://dx.doi.org/10.1038/s42003-023-05387-9

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