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Slack K(+) channels limit kainic acid-induced seizure severity in mice by modulating neuronal excitability and firing
Mutations of the Na(+)-activated K(+) channel Slack (KCNT1) are associated with terrible epilepsy syndromes that already begin in infancy. Here we report increased severity of acute kainic acid-induced seizures in adult and juvenile Slack knockout mice (Slack(−/−)) in vivo. Fittingly, we find exacer...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567740/ https://www.ncbi.nlm.nih.gov/pubmed/37821582 http://dx.doi.org/10.1038/s42003-023-05387-9 |