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Therapeutic vaccination following early antiretroviral therapy elicits highly functional T cell responses against conserved HIV-1 regions

‘Kick and kill’ cure strategies aim to induce HIV protein expression in latently infected cells (kick), and thus trigger their elimination by cytolytic T cells (kill). In the Research in Viral Eradication of HIV Reservoirs trial (NCT02336074), people diagnosed with primary HIV infection received imm...

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Detalles Bibliográficos
Autores principales: Kopycinski, Jakub, Yang, Hongbing, Hancock, Gemma, Pace, Matthew, Kim, Ellen, Frater, John, Stöhr, Wolfgang, Hanke, Tomás, Fidler, Sarah, Dorrell, Lucy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567821/
https://www.ncbi.nlm.nih.gov/pubmed/37821472
http://dx.doi.org/10.1038/s41598-023-42888-3