Cargando…
The role of inflammation and antioxidant defenses in the cardiotoxicity of doxorubicin in elderly CD-1 male mice
Doxorubicin (DOX) is a potent chemotherapeutic agent used against several cancer types. However, due to its cardiotoxic adverse effects, the use of this drug may be also life-threatening. Although most cancer patients are elderly, they are poorly represented and evaluated in pre-clinical and clinica...
Autores principales: | Reis-Mendes, Ana, Ferreira, Mariana, Duarte, José Alberto, Duarte-Araújo, Margarida, Remião, Fernando, Carvalho, Félix, Sousa, Emília, Bastos, Maria Lourdes, Costa, Vera Marisa |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567829/ https://www.ncbi.nlm.nih.gov/pubmed/37676301 http://dx.doi.org/10.1007/s00204-023-03586-1 |
Ejemplares similares
-
Role of Inflammation and Redox Status on Doxorubicin-Induced Cardiotoxicity in Infant and Adult CD-1 Male Mice
por: Reis-Mendes, Ana, et al.
Publicado: (2021) -
GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes
por: Karhu, S. Tuuli, et al.
Publicado: (2020) -
Inflammation as a Possible Trigger for Mitoxantrone-Induced Cardiotoxicity: An In Vivo Study in Adult and Infant Mice
por: Reis-Mendes, Ana, et al.
Publicado: (2021) -
Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone
por: Shi, Miaoying, et al.
Publicado: (2020) -
Selection of safe artemisinin derivatives using a machine learning-based cardiotoxicity platform and in vitro and in vivo validation
por: Kadioglu, Onat, et al.
Publicado: (2021)