Comparative metabolism of aflatoxin B(1) in mouse, rat and human primary hepatocytes using HPLC–MS/MS

Aflatoxin B(1) (AFB(1)) is a highly hepatotoxic and carcinogenic mycotoxin produced by Aspergillus species. The compound is mainly metabolized in the liver and its metabolism varies between species. The present study quantified relevant AFB(1)- metabolites formed by mouse, rat, and human primary hep...

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Detalles Bibliográficos
Autores principales: Gerdemann, Andrea, Cramer, Benedikt, Degen, Gisela H., Veerkamp, Jannik, Günther, Georgia, Albrecht, Wiebke, Behrens, Matthias, Esselen, Melanie, Ghallab, Ahmed, Hengstler, Jan G., Humpf, Hans-Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Organ Toxicity and Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567917/
https://www.ncbi.nlm.nih.gov/pubmed/37794256
http://dx.doi.org/10.1007/s00204-023-03607-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567917/
https://www.ncbi.nlm.nih.gov/pubmed/37794256
http://dx.doi.org/10.1007/s00204-023-03607-z

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