OCT1-dependent uptake of structurally diverse pyrrolizidine alkaloids in human liver cells is crucial for their genotoxic and cytotoxic effects

Pyrrolizidine alkaloids (PAs) are important plant hepatotoxins, which occur as contaminants in plant-based foods, feeds and phytomedicines. Numerous studies demonstrated that the genotoxicity and cytotoxicity of PAs depend on their chemical structure, allowing for potency ranking and grouping. Organ...

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Detalles Bibliográficos
Autores principales: Haas, Manuel, Ackermann, Gabriel, Küpper, Jan-Heiner, Glatt, Hansruedi, Schrenk, Dieter, Fahrer, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Genotoxicity and Carcinogenicity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567918/
https://www.ncbi.nlm.nih.gov/pubmed/37676300
http://dx.doi.org/10.1007/s00204-023-03591-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567918/
https://www.ncbi.nlm.nih.gov/pubmed/37676300
http://dx.doi.org/10.1007/s00204-023-03591-4

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