Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death

We identified cytoprotective small molecules (CSMs) by a cell-based high-throughput screening of Bax inhibitors. Through a medicinal chemistry program, M109S was developed, which is orally bioactive and penetrates the blood-brain/retina barriers. M109S protected retinal cells in ocular disease mouse...

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Detalles Bibliográficos
Autores principales: Matsuyama, Mieko, Ortega, Joseph T., Fedorov, Yuri, Scott-McKean, Jonah, Muller-Greven, Jeannie, Buck, Matthias, Adams, Drew, Jastrzebska, Beata, Greenlee, William, Matsuyama, Shigemi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568349/
https://www.ncbi.nlm.nih.gov/pubmed/37841588
http://dx.doi.org/10.1016/j.isci.2023.107916

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568349/
https://www.ncbi.nlm.nih.gov/pubmed/37841588
http://dx.doi.org/10.1016/j.isci.2023.107916

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