A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism

We explored the toxicity and mutagenicity of a wide range of xenobiotic nucleoside triphosphates to an Escherichia coli strain equipped with a nucleoside triphosphate transporter. This bacterial test provides a tool to evaluate and guide the synthesis of nucleotides for applications such as the prop...

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Detalles Bibliográficos
Autores principales: Blanchard, Aude, Abramov, Mikhail, Hassan, Camille, Marlière, Philippe, Herdewijn, Piet, Pezo, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568403/
https://www.ncbi.nlm.nih.gov/pubmed/37842681
http://dx.doi.org/10.1039/d3ra06172h
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author Blanchard, Aude
Abramov, Mikhail
Hassan, Camille
Marlière, Philippe
Herdewijn, Piet
Pezo, Valérie
author_facet Blanchard, Aude
Abramov, Mikhail
Hassan, Camille
Marlière, Philippe
Herdewijn, Piet
Pezo, Valérie
author_sort Blanchard, Aude
collection PubMed
description We explored the toxicity and mutagenicity of a wide range of xenobiotic nucleoside triphosphates to an Escherichia coli strain equipped with a nucleoside triphosphate transporter. This bacterial test provides a tool to evaluate and guide the synthesis of nucleotides for applications such as the propagation of non-natural genetic information or the selection of potential drugs.
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spelling pubmed-105684032023-10-13 A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism Blanchard, Aude Abramov, Mikhail Hassan, Camille Marlière, Philippe Herdewijn, Piet Pezo, Valérie RSC Adv Chemistry We explored the toxicity and mutagenicity of a wide range of xenobiotic nucleoside triphosphates to an Escherichia coli strain equipped with a nucleoside triphosphate transporter. This bacterial test provides a tool to evaluate and guide the synthesis of nucleotides for applications such as the propagation of non-natural genetic information or the selection of potential drugs. The Royal Society of Chemistry 2023-10-12 /pmc/articles/PMC10568403/ /pubmed/37842681 http://dx.doi.org/10.1039/d3ra06172h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Blanchard, Aude
Abramov, Mikhail
Hassan, Camille
Marlière, Philippe
Herdewijn, Piet
Pezo, Valérie
A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism
title A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism
title_full A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism
title_fullStr A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism
title_full_unstemmed A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism
title_short A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism
title_sort microbiological system for screening the interference of xna monomers with dna and rna metabolism
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568403/
https://www.ncbi.nlm.nih.gov/pubmed/37842681
http://dx.doi.org/10.1039/d3ra06172h
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