Non-steroidal FXR agonist cilofexor improves cholestatic liver injury in the Mdr2(-/-) mouse model of sclerosing cholangitis

BACKGROUND & AIMS: The nuclear receptor farnesoid X receptor (FXR) is a key regulator of hepatic bile acid (BA) and lipid metabolism, inflammation and fibrosis. Here, we aimed to explore the potential of cilofexor (GS-9674), a non-steroidal FXR agonist, as a therapeutic approach for counteractin...

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Detalles Bibliográficos
Autores principales: Fuchs, Claudia D., Sroda, Natalie, Scharnagl, Hubert, Gupta, Ruchi, Minto, Wesley, Stojakovic, Tatjana, Liles, John T., Budas, Grant, Hollenback, David, Trauner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568427/
https://www.ncbi.nlm.nih.gov/pubmed/37841639
http://dx.doi.org/10.1016/j.jhepr.2023.100874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568427/
https://www.ncbi.nlm.nih.gov/pubmed/37841639
http://dx.doi.org/10.1016/j.jhepr.2023.100874

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